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filingDate 2020-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2021-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2021-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-111110871-B
titleOfInvention Blood brain barrier crossing and in-situ brain glioma targeting nano diagnosis and treatment agent material and preparation method thereof
abstract The invention relates to a nanometer diagnosis and treatment agent material which can effectively cross blood brain barrier and target in-situ glioma and a preparation method thereof, in particular to a transferrin-based nanometer material and a preparation method thereof and application in preparing a nanometer diagnosis and treatment agent which can effectively cross blood brain barrier and target in-situ glioma; the transferrin-based nanomaterial comprises: iron saturated transferrin holo-Tf as carrier, and MnO loaded in the carrier 2 Nanocrystals and protoporphyrins; and the MnO 2 The nanocrystalline and protoporphyrin molecules are jointly encapsulated in transferrin to form a core-shell-like structure.
priorityDate 2020-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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