http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111110864-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0057 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6935 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-59 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 |
| filingDate | 2020-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111110864-B |
| titleOfInvention | Organic conjugated small molecule nano particle and preparation method and application thereof |
| abstract | The invention provides an organic conjugated micromolecule nano particle and a preparation method and application thereof, wherein the nano particle comprises organic conjugated micromolecules; and polystyrene maleic anhydride for surface modification of the organic conjugated small molecule; the organic conjugated micromolecules are selected from one or more of structures shown in formula I, formula II, formula III and formula IV; the polystyrene maleic anhydride has the structure of formula V. The organic conjugated micromolecule in the organic conjugated micromolecule nano particle is used as a photosensitizer, and the amphiphilic molecule PSMA is used for surface modification, so that the water solubility of the nano particle is enhanced, the interaction with bacteria is facilitated, and meanwhile, the organic conjugated micromolecule nano particle has higher active oxygen generation efficiency, which shows that the organic conjugated micromolecule nano particle has phototoxicity; the cyano group attached indicates that it contributes significantly to bactericidal activity, indicating that it has dark toxicity. Therefore, the nano-particles have the synergistic effect of phototoxicity and dark toxicity, and can be used as an antibacterial drug for treating infection caused by bacteria. The method is simple, does not need any functional modification, has high synthesis yield and is easy to realize industrialization. |
| priorityDate | 2020-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.