| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ea61bfc1125f5d765baa56a4d55c1d51 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-552
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-60 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-092
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-385
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-385
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-70 |
| filingDate |
2019-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f7b2c0d7d1fc0d92069ef3cfd2744a06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa2cd49c79266e167d58da89c7bb6a17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a952033b18facd6990fb1b84fe4c830 |
| publicationDate |
2020-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-111110838-A |
| titleOfInvention |
A kind of tilapia Streptococcus agalactiae vaccine and preparation method thereof |
| abstract |
The invention relates to a tilapia Streptococcus agalactiae vaccine and a preparation method thereof. A partial polypeptide sequence of a surface anchoring protein of Streptococcus agalactiae is analyzed and screened by the principle of bioinformatics as an antigen for vaccine preparation, and the A carbon nanotube-loaded surface protein system was constructed by chemical synthesis technology, and the candidate peptide antigens were combined with functionalized single-walled carbon nanometers to prepare a tilapia Streptococcus agalactiae subunit vaccine. The polypeptide antigen screened by the present invention can significantly increase the antibody level of the vaccinated tilapia than the inactivated vaccine, and can resist the challenge of highly virulent Streptococcus agalactiae. In addition, the polypeptide antigens screened in the present invention can be tightly and uniformly connected to the surface of the functionalized carbon nanotubes, and compared with a single polypeptide antigen group, the immunity of tilapia can be significantly improved. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113521265-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113521265-A |
| priorityDate |
2019-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |