| abstract |
The invention belongs to the field of drug synthesis, in particular to a synthesis process of cefathiamidine. 1,3-Diisopropylamidino-2-thioacetic acid hydrochloride first reacts with p-nitrobenzenesulfonyl chloride, and then undergoes amidation reaction with 7-ACA to generate cefathiamidine. The synthesis process of cefathiamidine provided by the invention is completed in one pot, the operation is simple, and the yield is significantly improved. |