| abstract |
The invention belongs to the technical field of medicine, and in particular relates to a preparation method of parecoxib sodium. Using 5-methyl-3,4-diphenylisoxazole as a raw material, through sulfonation reaction, ammoniation reaction, propionylation reaction and salt formation, parecoxib sodium is obtained. The reaction is mild and easy to operate, greatly reduces the generation of HCl gas, the reaction time is short, the product yield is high, and it is suitable for industrial production. |