http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111100080-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-08 |
| filingDate | 2019-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111100080-B |
| titleOfInvention | Preparation method of letrozole |
| abstract | The invention discloses a preparation method of letrozole, which comprises the following steps: adding p-cyanobenzaldehyde and triazole into a solvent, and reacting to obtain 4- (1- (1H-1,2, 4-triazole) hydroxymethyl) benzonitrile; adding thionyl chloride to the above product; adding the product and tert-butyl alcohol into a solvent, adding a catalyst, and reacting to obtain 4- (1- (1H-1,2, 4-triazole) chloromethyl) benzoyl tert-butylamine; adding the product into a solvent and a Grignard reagent, and reacting to obtain 4,4' - ((1H-1, 2, 4-triazole-1-yl) methyl) bis (N- (tert-butyl) benzamide); adding phosphorus oxychloride, and reacting to obtain letrozole. The reaction routes of the invention are mild, do not relate to reactions under harsh conditions, do not relate to high-risk processes, and are suitable for industrialization. |
| priorityDate | 2019-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 80.