| abstract |
The present invention relates to 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazine-1-yl)-phenyl Amino]-pyrimidin-4-yl}-1-methyl-urea and crystal forms of its salts. More specifically, the present invention relates to 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazine-1- (base)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea, new anhydrous and hydrated crystalline forms, amorphous and anhydrous monophosphate and hydrochloride salts including its dihydrate polymorph. The present invention also provides methods for the preparation of the different crystal forms, compositions comprising them, and methods of treatment using them. |