| abstract |
The invention discloses a preparation method of an alkyl nitrile compound. The present invention provides a method for preparing an alkyl nitrile compound shown in formula I, which comprises the following steps: in a solvent, in the presence of an additive and a catalyst, mixing Zn(CN) 2 with a compound shown in formula II The alkyl halide is subjected to the following coupling reaction to obtain the alkyl nitrile compound shown in formula I; the additive includes a base; the catalyst includes a nickel compound and a phosphine ligand; the The nickel-based compound is one or more of zero-valent nickel, monovalent nickel salt and divalent nickel salt; when the nickel-based compound contains zero-valent nickel or divalent nickel salt, the catalyst also includes reducing agent. The preparation method of the invention can realize the cyanation of the alkyl halide simply and efficiently with an inexpensive catalytic system, and also has good functional group compatibility and substrate universality. |