http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111097052-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6929 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-537 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-64 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-537 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 |
| filingDate | 2020-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111097052-B |
| titleOfInvention | Amphiphilic prodrug for active targeted therapy of tumors and preparation method and application of nanoparticles of amphiphilic prodrug |
| abstract | The prodrug for active targeted therapy of tumors is an amphiphilic prodrug containing a targeted head group, which is formed by coupling a small molecule connecting group with a hydrophobic anti-tumor drug and an active targeted hydrophilic short peptide, wherein the small molecule connecting group is a small molecule connecting group containing a thioketone bond. The amphiphilic prodrug containing the targeting head group can be self-assembled in water to form nanoparticles with a shell layer of hydrophilic short peptide and a core of hydrophobic micromolecular antitumor drug. Because the hydrophilic short peptide on the surface of the nano-particles can be specifically combined with receptors on tumor cells or tissues, the nano-particles can actively target to tumor parts and be enriched, the concentration of small-molecule antitumor drugs on the tumor parts is improved, the proliferation of the tumor cells is effectively inhibited, meanwhile, the toxic and side effects of the antitumor drugs on normal cells and tissues are reduced, and the active targeted therapy of tumors is realized. |
| priorityDate | 2020-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 62.