| abstract |
Enfufungin derivative triterpenoid antifungal compounds are useful in the treatment or prevention of fungal infections that occur in or under acidic conditions of pH less than about 7 due to their unexpected enhanced efficacy under acidic conditions. The enfufungin derivative triterpenoid (or a pharmaceutically acceptable salt or hydrate thereof) is an inhibitor of (1,3)-β-D-glucan synthesis and is suitable for treatment or prevention in patients with Yeast or fungal infections, such as those found in fungal abscesses, pyogenes, or upper gastrointestinal infections, in anatomical regions of low pH (eg, the vaginal cavity) or under acidic local environmental conditions. |