http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111088346-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_71de0b426be6a23c375c5536cbe2ad60 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6858 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6883 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6858 |
| filingDate | 2018-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_809dfb7b687b1777e543ca7045e01784 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_698652564630cbdb731e2707cefca6d9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1566eb41c769d26bee960ccf79042d7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d85bf79e375a769a45714e74ea254fff |
| publicationDate | 2020-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111088346-A |
| titleOfInvention | Method for distinguishing ramipril personalized medicine by mass spectrometry through product detection |
| abstract | The invention provides a method for distinguishing ramipril personalized medicine by Mass spectrometry through detecting products, which comprises the following steps: respectively designing a multiple amplification primer and an extension primer according to a plurality of target SNP sites to be detected; preparing a multiple amplification primer reaction system and an extension primer reaction system; in a reaction system, a plurality of sets of primers are used for simultaneously and respectively carrying out amplification and single base extension reaction on a plurality of target SNP sites; and (3) carrying out flight time mass spectrometry on the product obtained after the single base extension reaction, identifying the genotype of SNP (single nucleotide polymorphism) related to different drug metabolism according to the products of the extension primers with different molecular weights represented by mass spectrum peaks, and guiding the individual administration of the antihypertensive drug ramipril. The method can simultaneously detect 2 SNP sites related to the drug metabolism of ramipril, and has the advantages of low cost, no need of synthesizing probes, short time consumption, simple and convenient result analysis and extremely wide application field. |
| priorityDate | 2018-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 92.