Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b5b0cce18e5badc55c091663cce7b572 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-20 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-907 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
filingDate |
2018-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52c6d474cbbb6b2343ae99653a98ba2f |
publicationDate |
2020-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
CN-111088253-A |
titleOfInvention |
CRISPR single-base donor repair system for HBB-28 thalassemia gene |
abstract |
The invention discloses a CRISPR single-base donor repair system for HBB-28 thalassemia gene and the application of the repair system in the preparation of a therapeutic agent for HBB-28 thalassemia gene therapy. The CRISPR single-base donor repair system comprises: (1) a CRISPR/Cas expression plasmid, and (2) a donor comprising a normal HBB gene and a sequence that blocks re-edited nonsense mutant bases. The repair system of the present invention can be used for the treatment of HBB-28 thalassemia. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109266652-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113512535-A |
priorityDate |
2018-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |