http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111087475-B
Outgoing Links
Predicate | Object |
---|---|
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-734 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-02 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0682 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-605 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-50 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 |
filingDate | 2019-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2022-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2022-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-111087475-B |
titleOfInvention | FGF21 fusion proteins and methods for inhibiting degradation thereof |
abstract | The invention discloses an FGF21 fusion protein, which comprises: (1): a glucagon-like polypeptide 1(GLP-1) variant of the amino acid sequence shown in SEQ ID NO. 4, a linker peptide of the amino acid sequence shown in SEQ ID NO. 6, an Fc portion of a human IgG4 variant antibody of the amino acid sequence shown in SEQ ID NO. 8, and a fibroblast growth factor 21(FGF21) variant of the amino acid sequence shown in SEQ ID NO. 10; or (2): and (2) the fusion protein which is derived from the (1) and has the activity of FGF21 fusion protein, wherein the amino acid sequence in the (1) is substituted, deleted or added with one or more amino acids. The invention also discloses a method for inhibiting degradation of FGF21 fusion protein, which comprises adding a C1 protease inhibitor into a culture medium. The method of the invention can effectively inhibit the degradation of FGF21 fusion protein. |
priorityDate | 2019-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1059.