http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111087401-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-10 |
| filingDate | 2019-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111087401-B |
| titleOfInvention | Novel method for establishing spiro ring on 2-aryl quinazoline-4 (3H) -ketone compound |
| abstract | The invention discloses a novel method for establishing a spiro ring on a 2-aryl quinazolinone compound, which is realized by a brand-new C-H activation method of cyclopropenone. The method takes 2-aryl quinazolinone compounds and cyclopropenone compounds as raw materials, and forms C-C bonds on aromatic rings through continuous C-H activation/cyclization reaction catalyzed by transition metal in the presence of silver salt and acid, and cyclizes to synthesize the cyclopentadiene spiro pyrrole [1,2-b ] quinazolinone derivatives. Compared with the traditional method, the method has simple steps, easily obtained raw materials and wide application range of the substrate; realizes the construction of two C-C bonds and one C-N bond in one pot, obtains a series of products of multi-element ring-merging and spiral rings with high yield, and is beneficial to large-scale production and industrial application. |
| priorityDate | 2019-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 53.