http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111072500-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C221-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C215-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C223-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C221-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-28 |
| filingDate | 2019-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111072500-B |
| titleOfInvention | A kind of preparation method of ambroxol hydrochloride |
| abstract | The present invention relates to a kind of preparation method of ambroxol hydrochloride, this method comprises the following steps: after o-nitrobenzaldehyde is carried out aldehyde group protection first, under catalyst NiCoB/TiO 2 , hydrazine hydrate is reduced to obtain compound 3; Under the action of bromine and hydrogen peroxide, a bromination reaction occurs, and deprotection generates compound 2; and the reductive amination of aldehyde with trans-4-aminocyclohexanol under the action of catalyst NaBH(OAc) 3 and LiClO 4 Reaction, salt formation to obtain ambroxol hydrochloride. The invention has mild conditions, simple steps, environmental friendliness, easy storage of raw materials and high yield, and is suitable for industrialized production. |
| priorityDate | 2019-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 63.