| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_773b3092daa1a70df8e12701a76e80f9 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2603-74 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-08 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-62 |
| filingDate |
2019-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_483fc7fa80781a7db0cfde795785431a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7305c99bf07124fdc22a05d3f0257f34 |
| publicationDate |
2020-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-111072491-A |
| titleOfInvention |
A kind of preparation method of memantine hydrochloride |
| abstract |
The present invention provides a method for preparing memantine hydrochloride, which comprises the following steps: using 1-bromo-3,5-dimethyladamantane and formamide as an amination reagent to replace a bromine substituent, and then using Sodium hydroxide solution is used as a hydrolysis reagent to hydrolyze the carboxamide group to obtain an amino substituent, and finally to form a salt and crystallize to obtain the finished product memantine hydrochloride. The preparation conditions of this method are relatively mild, the raw materials are easily available and the cost is lower, and the obtained product has With good purity and high yield, the three wastes produced are less, and it has a good industrial production prospect. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111960949-A |
| priorityDate |
2019-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |