http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111057080-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-025 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-02 |
| filingDate | 2019-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111057080-B |
| titleOfInvention | A kind of preparation method of boron-containing indolinone derivative |
| abstract | The invention discloses a preparation method of boron-containing indolinone derivatives, in particular to a method for synthesizing boron-containing indolinone derivatives through the cyclization reaction of copper-catalyzed o-iodoaniline derivatives and biboronic acid pinacol esters , belongs to the field of organic synthesis. The method uses o-iodoaniline derivatives and pinacol biboronate as raw materials, and under the catalysis of copper catalyst, through the joint action of ligands and basic compounds, in an organic solvent, the reaction is carried out at a temperature of 40-140° C. , and the boron-containing indolinone derivatives are obtained by post-treatment after the reaction. The invention uses easily prepared o-iodoaniline derivatives and commercially available pinacol esters as raw materials, and realizes the rapid construction of boron-containing indolinone derivatives by constructing one ring and two chemical bonds in one step. The reaction conditions are mild, the operation is simple, and the reaction raw materials are readily available, the substrates are widely applicable, and the target products are easily separated. |
| priorityDate | 2019-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 119.