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filingDate 2019-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f689fce43a1fddd855fe95bee61219f
publicationDate 2020-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-111044662-A
titleOfInvention Method for determining concentration of pregabalin in blood plasma by liquid chromatography-mass spectrometry
abstract The invention discloses a method for determining the concentration of pregabalin in blood plasma by liquid chromatography-mass spectrometry, which adopts a liquid chromatography-mass spectrometry system to determine, firstly takes a sample to be determined, adds a certain amount of mixed organic solvent to extract, pretreats, separates by a chromatographic column, and detects by a mass spectrometer. The method is rapid, accurate, high in sensitivity and simple and convenient to operate, and provides a basis for the blood concentration determination of the pregabalin; the linear range of the plasma standard curve of the method is 0.05-15 mu g/mL, the precision RSD in batch and between batches is less than +/-15%, and the method is suitable for measuring the concentration of pregabalin in plasma.
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