http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111039796-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7458ec7a5e228caf43c7131a64b6fbf9 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-68 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-52 |
| filingDate | 2019-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_68221e2a12ec6ee0d0c6d70933c92b6f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3f79f586de7ca3a5c8b3c137901f7bae http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_490e6713b9b1efaa45ac0c199c1abaab |
| publicationDate | 2020-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111039796-A |
| titleOfInvention | A new method for the synthesis of 4'-chloro-2-aminobiphenyl |
| abstract | The invention discloses a new method for synthesizing 4'-chloro-2-aminobiphenyl. It uses o-bromoaniline and p-chlorobenzeneboronic acid as starting materials. o-bromoaniline, 1-2 equivalent of p-chlorobenzeneboronic acid, 1-3 equivalent of alkali, 1-2 mol% palladium catalyst are placed in the reactor, add the mixed solution of water or water-organic solvent as reaction solvent, Stir at 60 o C-100 oC for 12-24 hours. After the reaction was completed, it was cooled to room temperature, and then extracted with an organic solvent. After spin-drying the organic solvent, the product is obtained by separation. The advantages of the present invention: 1) The cheap o-bromoaniline is used as the starting material; 2) The method uses a simple palladium salt as the catalyst, without the participation of ligands; 3) The method does not require the protection of inert gas, and can be carried out in the air 4) Complete in one step in water or water phase system; 5) The post-processing of this method is simple, and the separation of product and reaction system can be achieved through simple organic solvent extraction; 6) This method 4'-chloro-2-amino linker The yield of benzene is high. |
| priorityDate | 2019-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 73.