http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111035646-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J73-003 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-585 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J73-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-585 |
| filingDate | 2020-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111035646-B |
| titleOfInvention | Application of limonin in preparation of medicine for treating and preventing autoimmune orchitis |
| abstract | The invention belongs to the technical field of biological medicines, and discloses application of limonin in preparation of a medicine for treating/preventing autoimmune orchitis. The method comprises the steps of taking citrus seeds rich in resources in China as raw materials, obtaining an orange seed ethanol extract through ethanol cold leaching extraction, extracting through ethyl acetate, concentrating, performing silica gel column chromatography, and performing extraction with cyclohexane: acetone gradient elution, in which the crude fraction Fr6 is chromatographed again on a silica gel column, eluting with cyclohexane: gradient eluting with acetone to obtain powdery white solid, and recrystallizing to obtain white needle crystal as limonin. The limonin provided by the invention has the advantages of simple preparation process, convenience in operation and large and easily-obtained sample amount. Pharmacological experiments show that the limonin protects autoimmune testicular inflammatory injury by reducing inflammatory factors (IL-1 beta, IL-6, TNF-alpha and the like) and increasing the content of male hormone testosterone (T), has the effect of resisting autoimmune orchitis, and can be developed into a medicament for treating/preventing the autoimmune orchitis. |
| priorityDate | 2020-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 142.