| abstract |
The invention discloses a method for synthesizing a chiral phthalide compound and a deuterated compound thereof. The method comprises dissolving a rhodium metal catalyst, zinc powder, additives and ligands in a dry solvent in an inert gas atmosphere, and then adding 3-alkylene base phthalate compound or 3-arylene phthalate compound reaction substrate, then add water or deuterium water to react at 40 ~ 70 ℃ to obtain the target product, and its general reaction formula is as follows: . The reagent of the invention is cheap and easy to obtain, the method is simple, the operation is convenient, and the atom economy is strong, and is suitable for conventional preparation. |