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filingDate 2018-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2021-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2021-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-111012916-B
titleOfInvention Surface-modified sponge spicule and preparation method and application thereof
abstract The invention discloses a surface-modified sponge spicule and a preparation method and application thereof, and provides a sponge spicule of which the surface is modified with aliphatic alkyl, aromatic alkyl or aromatic fat group. The invention has simple synthesis process, easily controlled reaction conditions and stable physicochemical property of the product, the product can physically adsorb one or more polypeptides or proteins, and further promotes the skin or percutaneous administration of the polypeptides and proteins through the action of the microneedles, and has wide application prospect and huge potential market value.
priorityDate 2018-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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