http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111004624-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1007 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61N2005-0612 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1029 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61N5-0601 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K11-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61N5-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-12 |
| filingDate | 2019-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111004624-B |
| titleOfInvention | Preparation of a near-infrared fluorescent probe with PTT effect and aggregation-induced luminescence enhancement effect |
| abstract | The invention discloses the preparation of a near-infrared fluorescent probe with PTT effect and aggregation-induced emission enhancement effect. The fluorescent probe is composed of a traditional fluorescent nucleus IR-780 iodide with near-infrared excitation and emission and an aggregation-induced emission molecule TPE is formed by connecting oxygen ether bonds. Compared with IR‑780 iodide, the fluorescence intensity of the probe is significantly enhanced in ethanol solution, and it exhibits a typical AIEE effect in mixed solvent; at 0.3µM concentration, it can selectively produce photothermal killing against various cancer cells And this concentration has no obvious killing effect on normal cells, and has significant killing selectivity. The probe is simple to prepare, has good photostability and photothermal conversion ability, and both excitation and emission are in the near-infrared region, and the background interference and damage to the organism are small. It has the function of integrated diagnosis and treatment, and is expected to be used in in clinical research. |
| priorityDate | 2019-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.