| abstract |
The invention belongs to the field of organic chemical synthesis, and relates to a method for synthesizing a polysubstituted pyridine derivative and its application. In the following, the polysubstituted pyridine is synthesized only through a one-step reaction, and the use of dangerous and controlled drugs is not involved in the reaction, which provides a simple, safe, efficient and environmentally friendly way for synthesizing the polysubstituted pyridine. The reaction of the present invention can also be used for the synthesis of drug molecules, such as the one-step synthesis of the drug molecule etoricoxib and its derivatives. In addition, the products obtained by the present invention can be further derivatized to obtain various types of active molecules containing pyridine functional groups, such as two step-by-step synthesis of the active molecule 2-SORA. |