abstract |
Provided herein are antibodies that bind to a Fagaceae plant allergen, a Fagaceae plant-associated allergen, birch pollen, or Bet v 1; compositions comprising the antibodies; nucleic acids encoding the antibodies; and methods of using the antibodies method. According to certain embodiments, the antibody is a fully human monoclonal antibody that binds to Bet v 1. The antibodies can be used to bind Bet v 1 in vivo, thereby preventing the allergen from binding to pre-formed IgE on the surface of mast cells or basophils. In this case, the antibody acts to prevent the release of histamine and other inflammatory mediators from mast cells and/or basophils, thereby ameliorating the adverse response to the Fagacea plant allergen in susceptible individuals. |