http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110982896-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4baad51ed73d81d9c8abbff4db2dcf97 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-136 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-178 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6883 |
| filingDate | 2020-01-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8cffae106bec8736d27d069bcbbb8205 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7506828158084b785e06d9eaf45bec35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_51600bad234b2e79e1239cf131a03736 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_215332631e18a9845268fb92ff4d32d3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f9009a72f894319207438a4947ec7e78 |
| publicationDate | 2020-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110982896-A |
| titleOfInvention | miR-146a as a potential biomarker in polymyositis/dermatomyositis |
| abstract | The invention discloses the application of miR-146a as a potential biomarker in the development of polymyositis/dermatomyositis diagnostic reagents or prevention and treatment drugs. By isolating peritoneal macrophages from human peripheral blood mononuclear cells from healthy donors and treating them with miR-146a mimics, miR-146a inhibitors, small interfering RNAs targeting IL-17 receptor A and REG3A, revealed The expression of miR-146a is closely related to the pathogenesis of polymyositis/dermatomyositis, and down-regulation of miR-146a expression can improve the migration ability of macrophages and promote inflammatory infiltration in PM/DM patients. The invention provides a new potential serological marker for diagnosing polymyositis/dermatomyositis, and also provides a new target for the prevention and treatment of polymyositis/dermatomyositis. |
| priorityDate | 2020-01-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 220.