http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110981949-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-795 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-765 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-77 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-795 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-77 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-765 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-10 |
| filingDate | 2019-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110981949-B |
| titleOfInvention | Preparation method of ketamine antigen |
| abstract | The invention discloses a preparation method of a ketamine antigen, which comprises the following steps: s1, using ketamine hydrochloride as raw material, and protecting amino group with 2-trimethylsilyl ethoxycarbonyl chloride (TeocCl); s2, reducing the ketamine after the amino protection by sodium borohydride to obtain alcohol through carbonyl on cyclohexane; s3, reacting the alcohol obtained in the step b) with succinic anhydride to lead out a coupling arm containing carboxyl; s4, coupling the product obtained in the step c) with macromolecular protein, and removing amino protection to obtain the ketamine antigen. The invention has the following beneficial effects: the antigen synthesized by the invention reserves secondary amine active groups in ketamine molecules, and a coupling arm is led out from cyclohexane in a molecular structure, so that the molecular structure of ketamine is reserved to the greatest extent, and the obtained antigen has stronger specificity and higher sensitivity. |
| priorityDate | 2019-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 73.