http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110963959-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12aaf32a6b02a9edade767ac0dda65e2 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-42 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-42 |
| filingDate | 2018-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc4c4cd391ce211dba9f9622705ef557 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3b5c21783d33b9bd9aa1397e632518b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d8b75fd700e5144708c0abc31423753 |
| publicationDate | 2020-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110963959-A |
| titleOfInvention | A kind of preparation method of synthesizing N-protected and unprotected 3-hydroxy-4,4-dimethylpiperidine |
| abstract | The invention discloses a preparation method of 3-hydroxy-4,4-dimethylpiperidine and N-protected 3-hydroxy-4,4-dimethylpiperidine and intermediates thereof, mainly solving the problem of N-protection And the technical problem that unprotected 3-hydroxy-4,4-dimethylpiperidine synthesis technique lacks, comprises the following steps: take compound II (2,2-dimethyl-4-pentenoate) as raw material, The olefinic bond is oxidized to generate compound III; compound III and compound IV undergo aldoamine condensation reaction to generate compound V; compound V undergoes ring closure reaction to generate compound VI; then hydrolysis and decarboxylation generate compound VII; the N of compound VII piperidine ring is debenzyl group Protecting group obtains compound VIII; Add other protecting groups to obtain compound IX; Compound IX finally obtains compound I (3-hydroxy-4, 4-dimethylpiperidine and N-protected 3-hydroxy-4 through reducing carbonyl group, 4-Dimethylpiperidine). |
| priorityDate | 2018-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 88.