| abstract |
The application provides an aspirin-containing medicine, its preparation method, pharmaceutical composition and application. The drug includes nucleic acid nanoparticles and aspirin, and aspirin is mounted on the nucleic acid nanoparticles; the nucleic acid nanoparticles include a nucleic acid domain, the nucleic acid domain includes a sequence, b sequence and c sequence, and the a sequence includes a1 sequence or a1 sequence occurs at least A sequence of base insertion, deletion or substitution, b sequence contains b1 sequence or b1 sequence has at least one base insertion, deletion or substitution, c sequence contains c1 sequence or c1 sequence has at least one base insertion, deletion or substitution the sequence of. The aspirin-containing medicine provided by the present application, after the nucleic acid domain is modified by the target head, can have better targeting, can deliver aspirin stably, and has high reliability. |