http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110950899-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-10 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-022 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-337 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-02 |
| filingDate | 2019-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110950899-B |
| titleOfInvention | Photo-thermal reagent with ultra-efficient energy barrier-free rotor for photo-thermal therapy and preparation method and application thereof |
| abstract | The invention discloses a photo-thermal reagent with an ultra-efficient energy barrier-free rotor for photo-thermal therapy, a preparation method and application thereof, and belongs to the field of nano materials. The invention relates to a method for synthesizing a photothermal reagent based on a boron fluoride dipyrrole (BODIPY) precursor, and introduces-CF at a meso-position (tfm-BDP) 3 "non-energy barrier" rotor. tmf-BDP excited-state-CF under near-infrared laser irradiation (808nm) 3 Free to rotate, resulting in efficient conversion of light energy into heat energy. Importantly, after tmf-BDP is encapsulated into polymer nanoparticles, the-CF can still be maintained 3 Is free to rotate. Therefore, tfm-BDP NPs showed an ultra-high photothermal conversion efficiency of 88.3%. After intravenous injection of tfm-BDP NPs, even at safe intensity (0.3 Wcm) ‑2 808nm) can also induce complete tumor ablation in tumor-bearing mice. The 'rotor without energy barrier' strategy provides a new platform for further design of the anti-cancer treatment PPT medicament. |
| priorityDate | 2019-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.