| abstract |
The present invention relates to a protein deacetylase, a proteasome dual-target inhibitor and a pharmaceutically acceptable salt thereof, a stereoisomer thereof, a preparation method and application thereof, and the compound has the general formula I shown, The compound of the present invention has good anti-histone deacetylase activity, anti-proteasome activity and anti-tumor cell proliferation activity, and can be used for the preparation of the prevention or treatment of the disease caused by abnormal expression of histone deacetylase or abnormal proteasome. The present invention also relates to the pharmaceutical use of the composition containing the compound of the general formula I for the medicament of related mammalian diseases. |