| abstract |
The invention provides an injectable conductive hydrogel and a preparation method thereof. The catechol group on dopamine (DOPA) is used for complex reaction with Fe 3+ , and gelatin grafted with polyaniline with conductive activity is added to prepare it. Deconductive, dopamine-based injectable hydrogels. The preparation method of the hydrogel is simple, the reaction conditions are mild, the biocompatibility is good, and the conductivity of the gel can be adjusted by controlling the grafting rate of polyaniline, and due to the addition of dopamine, the hydrogel has a certain viscosity. Attachment, can be fixed on the myocardium and will not slip off due to the beating of the heart. In addition, the modified hydrogels can be used to load drugs that treat heart disease, such as resveratrol or dimethyloxalylglycine (DMOG). The hydrogel is injected into the diseased heart muscle to release the loaded drug. |