http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110938107-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J31-006 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J31-00 |
| filingDate | 2018-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110938107-B |
| titleOfInvention | Method and intermediate for preparing fulvestrant |
| abstract | The present invention relates to a method and an intermediate for preparing fulvestrant. The invention relates to a method for preparing an intermediate of fulvestrant. The method takes estradiol as a starting material, and after adding a protective group, intermediate 1 is obtained, and intermediate 1 is hydroxylated at the benzylic position to obtain intermediate 2, Intermediate 1 is hydroxylated to obtain intermediate 2, intermediate 2 is oxidized to obtain intermediate 3, and intermediate 3 is iodized with intermediate 4 (1,9-dibromononane to obtain intermediate 4, i.e. 1,9-diiodonane Alkane) condensation reaction obtains intermediate 5 (compound of formula I), intermediate 5 and intermediate 7 (4,4,5,5,5-pentafluoropentanol and p-toluenesulfonyl chloride are condensed and obtained by reacting with thiourea, that is, p-toluenesulfonic acid pentafluorothiourea) reaction to obtain intermediate 8, intermediate 8 is deprotected-reduced to obtain intermediate 9, and intermediate 9 is oxidized to obtain the target product. The method has the advantages of simple operation process, high yield and high purity to obtain fulvestrant, and is very suitable for industrialized large-scale production. |
| priorityDate | 2018-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 64.