http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110938003-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6552 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D319-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D319-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C215-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-655 |
| filingDate | 2018-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110938003-B |
| titleOfInvention | A kind of preparation method of fingolimod hydrochloride |
| abstract | The invention provides a preparation method of fingolimod hydrochloride. The method uses 2,2-disubstituent-5-hydroxymethyl-5-nitro-1,3-dioxane to react with halogenated reagent and triphenylphosphine to prepare corresponding Witting reagent, and then Octylbenzaldehyde undergoes Witting reaction, catalytic hydrogenation to reduce nitro group and carbon-carbon double bond, hydrolysis reaction to remove hydroxyl protecting group aldehyde or ketone to prepare fingolimod, and then form a salt with hydrogen chloride to obtain fingolimod hydrochloride. The method of the present invention has high reaction selectivity and yield, cheap and easy-to-obtain raw materials, high safety operability, mild reaction conditions, less waste water generation, and high purity of the obtained fingolimod, which is high-purity fingolimod hydrochloride The preparation of the salt provides a guarantee and facilitates the facile industrial production of fingolimod hydrochloride. |
| priorityDate | 2018-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 169.