http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110938003-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_14687eb1d34a9a00bd12725a2e42d611 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D319-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6552 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-655 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D319-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C215-28 |
| filingDate | 2018-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a7cd47acc202d3555b126d448215c01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8afb995a7895fe80e3cda4496c7cc370 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c69b2f56b0e5e3143c5c0243c02c762d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_128edcfb81fe388985361c06461b60b3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_25aaaa7e04fedf35ebfd2160e7f4d7c7 |
| publicationDate | 2020-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110938003-A |
| titleOfInvention | A kind of preparation method of fingolimod hydrochloride |
| abstract | The invention provides a preparation method of fingolimod hydrochloride. The method uses 2,2-disubstituent-5-hydroxymethyl-5-nitro-1,3-dioxane to react with halogenated reagent and triphenylphosphine in turn to prepare corresponding Witting reagent, and then react with para-n Octylbenzaldehyde is subjected to Witting reaction, catalytic hydrogenation to reduce nitro group and carbon-carbon double bond, hydrolysis reaction to remove hydroxyl protecting group aldehyde or ketone to prepare fingolimod, and then salify with hydrogen chloride to obtain fingolimod hydrochloride. The method of the invention has high reaction selectivity and yield, cheap and easy-to-obtain raw materials, high safety and operability, mild reaction conditions, less waste water generation, and the obtained fingolimod has high purity and is high-purity fingolimod hydrochloric acid. The preparation of the salt provides a guarantee for the easy and industrial production of fingolimod hydrochloride. |
| priorityDate | 2018-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 150.