http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110934867-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-433 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-433 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 |
| filingDate | 2019-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110934867-B |
| titleOfInvention | Application of Hao1 inhibitor in the preparation of drugs for inhibiting the formation of microenvironment before lung metastasis of tumor and preventing and treating lung metastasis of tumor |
| abstract | The invention discloses the application of a Hao1 inhibitor in the preparation of a medicine for inhibiting the formation of a microenvironment before lung metastasis of a tumor and preventing and treating the lung metastasis of a tumor. In the present invention, by constructing a breast cancer fat pad implantation model, it is found that Hao1 in the lung tissue of the tumor-negative mice is significantly up-regulated in the pre-metastatic stage. The applicant treated mice with the Hao1 inhibitor CCPST to detect the effects of CCPST on the concentration of oxalate in lung tissue, the expression of inflammatory factors and pro-metastasis-related factors, and the ability of breast cancer to metastasize in the lung tissue of tumor-bearing mice at the pre-metastatic stage. Provide basis for the preparation of drugs for preventing and treating lung metastasis of breast cancer. The compound CCPST can significantly inhibit the concentration of oxalic acid in lung tissue, the expression of inflammatory factors and pro-metastasis-related factors in the lung tissue of tumor-negative mice in the pre-metastatic stage, and inhibit the lung metastasis of breast cancer without obvious toxic and side effects, so it can be used for the preparation of drugs that effectively inhibit lung metastasis of breast cancer. . |
| priorityDate | 2019-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 189.