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filingDate 2018-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8911a8ee4e30cd36d76444d749b39760
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publicationDate 2020-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-110922395-A
titleOfInvention Novel crystal form of canagliflozin and preparation method thereof
abstract The invention relates to a crystal form H of canagliflozin and a preparation method thereof. The form H has an X-ray powder diffraction comprising 3 or more 2 Θ values selected from the group consisting of: 3.4 +/-0.2 degrees, 3.7 +/-0.2 degrees, 7.6 +/-0.2 degrees, 11.5 +/-0.2 degrees, 15.4 +/-0.2 degrees, 19.3 +/-0.2 degrees, 23.2 +/-0.2 degrees, 23.6 +/-0.2 degrees and 27.2 +/-0.2 degrees, wherein the onset value of the differential scanning calorimetry analysis of the crystal form H is between 100 and 110 ℃, and meanwhile, the thermogravimetric analysis of the crystal form H shows that the weight loss is 2.0 to 3.0 percent at the temperature of between 25 and 300 ℃. The crystal form H has the advantages of high purity, stable physicochemical property, good reproducibility, simple production process and suitability for industrial production.
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