| abstract |
The present invention relates to a preparation for inhibiting the adverse reaction of opioid analgesics and its application. The preparation contains 17-N-allylamino-17-demethoxygeldanamycin or/and its homologues One or more, the opioid analgesics include: morphine hydrochloride tablets, morphine sulfate sustained-release tablets, codeine phosphate tablets, morphine hydrochloride injection, pethidine hydrochloride injection, fentanyl injection wherein one or a combination of several. By adopting the technical scheme of the present invention, the chronic administration of 17-AAG with morphine can significantly inhibit the symptoms of urge withdrawal, and can significantly inhibit the physical tolerance and mental dependence of morphine. Analgesics have dual effects of anti-tumor and inhibition of opioid analgesic tolerance and dependence, which can reduce the use of other drugs. |