| abstract |
The invention belongs to the technical field of medicines, and in particular relates to a metronidazole tablet and a preparation method thereof. The preparation method comprises: pulverizing a metronidazole raw material and passing through a first mesh sieve to obtain metronidazole, the metronidazole The particle size is not greater than 300 microns; the metronidazole, filler and disintegrant are weighed according to the preset mass percentage and mixed evenly in a wet granulator, add binder to granulate, and pass through a second mesh sieve to obtain wet particles, wherein the particle size of the filler is not greater than 150 microns; the wet particles are dried and then granulated, added with a lubricant, and then placed in a mixer for mixing to obtain intermediate particles; Compression, coating and packaging to obtain metronidazole tablets. The preparation method for metronidazole tablets provided by the embodiments of the present invention has stable process, ensures the product quality of the finally obtained metronidazole tablets, has better dissolution rate, effectively improves its dissolution effect, and improves the quality and curative effect of metronidazole tablets . |