| abstract |
The present invention provides a class of isoindolinone-imide ring-1,3-diketone-2-ene compounds and preparation methods, pharmaceutical compositions and uses thereof, specifically, the present invention provides a class of the following formula ( The compound of I) or a pharmaceutically acceptable salt thereof, wherein Ar is an isoindolinone-imide group represented by the general formula (II), L does not exist, or is divalent, trivalent or tetravalent Linking group; X is a group represented by the general formula (III), and the definitions of other groups are as described in the specification. The compound of formula (I) is a class of autophagy regulators, especially mammalian ATG8 homologue regulators. |