http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110907422-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2021-6432 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2021-6417 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6428 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6486 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-64 |
| filingDate | 2019-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110907422-B |
| titleOfInvention | Based on Ti3C2Thrombin aptamer sensor and preparation method thereof |
| abstract | The invention relates to a Ti-based alloy 3 C 2 The thrombin aptamer sensor and the preparation method thereof belong to the technical field of biological analysis and detection. Solves the technical problems that the antibody used by the traditional thrombin detection method is difficult to prepare and store, and the related reaction is complex and time-consuming. The invention provides a Ti-based alloy 3 C 2 The thrombin aptamer sensor is prepared from a single layer of Ti 3 C 2 And its binding to Ti 3 C 2 A fluorescein-labeled thrombin aptamer composition on the surface; the sequence of the fluorescein-labeled thrombin aptamer is as follows: 5 '-FAM-GGT TGG TGT GGT TGG-3'. The invention adopts Ti 3 C 2 The thrombin sensor is constructed by materials, and Ti is widened 3 C 2 The method is applied to the biological field, and an excellent nano detection platform is constructed; compared with the traditional antibody, the thrombin aptamer used as a thrombin recognition agent has the advantages of low price, simple and convenient synthesis, easy storage and quick reaction. The invention provides a preparation method for preparing Ti-based alloy 3 C 2 The thrombin aptamer sensor has the characteristics of high specificity and high sensitivity, and the detection limit of the thrombin aptamer sensor on thrombin is 2.5 multiplied by 10 â11 mol/Lă |
| priorityDate | 2019-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 49.