http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110904224-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eec19c18115f3b92ff1d1f2ab988f7d5 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-682 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0054 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-682 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6886 |
| filingDate | 2019-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c1fe4065abe77cce34a9f4a6d7575e90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_525962e44662db72ffae9c6e3a257d67 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_57914f5131ce001145c153e1f0a10f3e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e89af0563987e9735e4993a6a420a102 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35f08d74d74e9180ec767853daf3cfae |
| publicationDate | 2020-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110904224-A |
| titleOfInvention | Manganese dioxide/nucleic acid probe composite nanoprobe capable of signal specific amplification and preparation method and application thereof |
| abstract | The invention provides a manganese dioxide/nucleic acid probe composite nanomaterial, comprising manganese dioxide, a cationic polymer and a nucleic acid probe; the nucleic acid probe is composed of double-stranded DNA molecules and single-stranded DNA molecules. The manganese dioxide/nucleic acid probe composite nanoprobe provided by the present invention can realize the specific signal amplification of tumor cells. First, the composite nanoprobe can open double-stranded nucleic acid under the trigger of microRNA highly expressed in tumor cells to generate fluorescent signal; secondly , specifically and rapidly release single-stranded nucleic acid in tumor cells to achieve specific amplification of tumor cell fluorescence signals. The composite nanoprobe can realize signal amplification of tumor cells, and this signal-specific amplification strategy enhances the specificity of nucleic acid detection by virtue of the advantages of nanoparticles. Moreover, the preparation is simple, the conditions are mild, the detection signal in normal cells can be effectively reduced, and the method has universality and good application prospect. |
| priorityDate | 2019-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.