http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110903393-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-7155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-569 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2866 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-577 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6869 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-577 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 |
| filingDate | 2019-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110903393-B |
| titleOfInvention | Polypeptide capable of binding IL6R alpha and application thereof |
| abstract | The invention relates to a polypeptide capable of binding IL6R alpha, which comprises 3 complementarity determining regions CDR1-3, wherein the sequence of CDR1 is or comprises the sequence shown in SEQ ID NO. 1, the sequence of CDR2 is or comprises one of the sequences shown in SEQ ID NO. 2-4, and the sequence of CDR3 is or comprises one of the sequences shown in SEQ ID NO. 5-7. According to the invention, a nano antibody VHH specifically combined with IL6R alpha is screened by preparing IL6R alpha protein, immunizing alpaca, utilizing a platform technology of phage library display nano monoclonal antibody and the like, the CDR sequence of the nano antibody is identified, and a humanized nano antibody is constructed; and simultaneously evaluating the function of the humanized antibody for blocking the combination of IL6 and IL6R by using an in vitro functional test. The invention provides a potential nano-antibody new drug for clinical treatment of autoimmune diseases, inflammatory diseases or tumor diseases such as rheumatoid arthritis and the like related to IL6 and a ligand thereof. |
| priorityDate | 2019-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 182.