http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110903353-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-56 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-02 |
| filingDate | 2019-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110903353-B |
| titleOfInvention | Method for preparing bremelanotide by solid-liquid phase combination |
| abstract | The invention discloses a method for preparing a bremelanotide by solid-liquid phase combination. The invention relates to a method for preparing a buminuo peptide, which synthesizes an AC-Nle-Asp-O-2-Phipr dipeptide fragment by a liquid phase method, a main chain and a side chain of Lys are respectively coupled and prolonged by peptide sequences to obtain Fmoc-His (Boc) -D-Phe-Arg (pbf) -Trp (Boc) -Lys (AC-Nle-Asp-O-2-Phipr) -royal resin, the main chain and the side chain are cyclized after cutting off a protecting group, the head and tail folding and cyclization are avoided, the problem of large folding and cyclization steric hindrance is solved, and the influence of the cyclized peptide on the non-cyclized peptide is reduced to the minimum due to the closer cyclization sites. In addition, alkali is not adopted for hydrolysis, and corresponding impurities are not generated. The synthetic method of the bremelanotide has the advantages of high purity and low cost, and is suitable for large-scale production. |
| priorityDate | 2019-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 117.