http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110894189-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-94 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-94 |
| filingDate | 2019-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110894189-B |
| titleOfInvention | Preparation method of erlotinib hydrochloride |
| abstract | The invention relates to a preparation method of erlotinib hydrochloride, which comprises the following steps: reacting 2-amino-4, 5-dimethoxybenzoic acid with formamide to generate a compound 5, and reacting the compound 5 with 3-ethynylaniline to generate a compound 3 after bromination reaction; the compound 3 reacts with 48% hydrobromic acid under the action of a catalyst to obtain a compound 2, and then the compound and iodoethyl methyl ether generate erlotinib hydrochloride under the action of alkali and the catalyst. The method has the advantages of mild conditions, low impurity content, safety, no pollution, environmental protection and suitability for industrial production. |
| priorityDate | 2019-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 96.