http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110885856-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2750-14143 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-485 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-17023 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-4813 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-864 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-02 |
| filingDate | 2019-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110885856-B |
| titleOfInvention | Controllable up-regulation of ACE2 expression vector for targeted prevention and treatment of hypoxic pulmonary hypertension |
| abstract | The invention discloses an expression carrier for controllable up-regulation of ACE2 targeted prevention and treatment of hypoxic pulmonary hypertension. The present invention constructs an HRE-enhanced, Tie2 promoter-driven ACE2 expression vector, which is specifically positioned in vascular endothelial cells through the Tie2 promoter, and at the same time, uses HIF-1α to specifically activate HRE only in hypoxic pulmonary vascular endothelial cells, thereby up-regulating Expression of ACE2. The present invention finds that the constructed expression vector is not only targeted, but also can controllably and effectively up-regulate the expression of ACE2 in hypoxic pulmonary microvascular endothelial cells according to the degree of hypoxia, and then regulate pulmonary artery smooth muscle cells to achieve hypoxia controllable It can selectively and targetedly inhibit the contraction of pulmonary arteries and reverse the structural reconstruction of pulmonary arteries, and provide effective means and strategies for the prevention and treatment of hypoxic pulmonary hypertension and other diseases. |
| priorityDate | 2019-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 181.