http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110882398-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6923 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y30-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y40-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B82Y5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B82Y30-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B82Y40-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-12 |
| filingDate | 2019-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110882398-B |
| titleOfInvention | A kind of oral curcumin-nanodiamond composite and preparation method thereof |
| abstract | The invention belongs to the technical field of pharmaceutical preparations, and discloses an oral curcumin-nanodiamond composite and a preparation method thereof. In the present invention, carboxylation and acid chloride treatment of nano-diamonds are carried out successively, and then the acid-chlorinated nano-diamonds are reacted with polyethylene glycol vitamin E succinate to obtain polyethylene glycol vitamin E succinate covalently modified nano diamonds, and then Encapsulating curcumin to obtain curcumin nano-diamond composite. The covalent modification of polyethylene glycol vitamin E succinate effectively solved the dispersibility and in vitro and in vivo stability problems of nanodiamond as a drug delivery carrier. After encapsulating curcumin, the solubility and gastrointestinal retention of the drug were significantly improved and permeability, significantly improving the oral bioavailability of the drug. |
| priorityDate | 2019-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 66.