http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110878098-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2019-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110878098-B |
| titleOfInvention | Preparation method of BCL-2 inhibitor-vetila |
| abstract | The invention discloses a preparation method of BCL-2 inhibitor-Vittra, which mainly comprises six steps, 1) taking VM1 and VM2 as reaction starting materials, and carrying out butt-joint reaction under the action of alkali catalysis to prepare an intermediate V1; 2) the intermediate V1 reacts with Boc piperazine under the action of base catalysis to prepare an intermediate V2; 3) removing Boc protection from the intermediate V2 under the action of an acid reagent to prepare an intermediate V3; 4) the intermediate V3 and VM3 are heated to react to form Schiff base, and the Schiff base is converted into secondary amine under the action of a reducing agent to prepare an intermediate V4; 5) the intermediate V4 reacts with VM4 under the action of a condensing agent to prepare an amide compound intermediate V5; 6) and removing the benzenesulfonyl protecting group from the intermediate V5 under the catalysis of a catalyst to obtain a final product Venetocclax. Compared with the prior art, the process route has the advantages of short steps, simple and easy reaction, and is suitable for large-scale industrial production. |
| priorityDate | 2019-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 73.