http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110876819-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2400-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-258 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L31-148 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L31-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L31-10 |
| filingDate | 2019-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110876819-B |
| titleOfInvention | Biological material or medical apparatus with endothelial cell selective gene delivery surface and preparation method thereof |
| abstract | A biomaterial or medical device with endothelial cell selective gene delivery surface and a preparation method thereof, the preparation comprises: (1) amination on the surface of the biological material or the medical instrument; (2) surface functional modification of biological materials or medical instruments; (3) preparing a streptavidin modified biological material or a medical instrument; (4) the result is a biomaterial or medical device having an endothelial cell-selective gene delivery surface. The invention can transfect endothelial cells on the surface of the biological material or the medical appliance in situ, promote the proliferation and the migration of the cells on the surface of the biological material or the medical appliance and realize the rapid endothelialization. The method is simple and easy to operate; the polypeptide and the gene compound used in the invention have biocompatibility and biodegradability, and the used materials are safe, nontoxic and non-immunogenic; the polypeptide with biotin contacts with proteases on the surface of endothelial cells, is degraded enzymatically, is beneficial to the responsive release of a gene compound, and then transfects the endothelial cells with high efficiency to realize surface transfection. |
| priorityDate | 2019-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 79.