| abstract |
The invention discloses a preparation method of an obeticholic acid liposome tablet, which is characterized in that the obeticholic acid liposome consists of obeticholic acid, lecithin and cholesterol, and then the obeticholic acid liposome and proper auxiliary materials are prepared into the obeticholic acid liposome tablet. The obeticholic acid liposome comprises the following components: 1 part of obeticholic acid, 5-10 parts of lecithin and 1-5 parts of cholesterol. Obeticholic acid liposome tablet contains the following components: 1 part of obeticholic acid liposome, 1-5 parts of filler, 0-0.5 part of disintegrating agent, 0-0.5 part of adhesive and 0-0.2 part of lubricant. The technical scheme of the invention utilizes the advantages of the liposome, improves the drug absorption and utilization of obeticholic acid, and can effectively reduce the administration dosage. |